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Test Code HEPATITIS B CORE, TOTAL ANTIBODY HEPATITIS B CORE, TOTAL ANTIBODY

Department

Immunology

Group Components

HEPATITIS B CORE ANTIBODY

Specimen Type

Serum

Container

No additive with gel (gold top)

Special Requirements

Centrifuge sample within 24 hours post draw.

Standard Volume

4.5ml

Minimum Volume

3ml

Pediatric Volume

0.5ml

Method

Chemiluminescent Microparticle Assay

Ship Temperature

Refrigerated

Stability Room Temp

72 hours

Stability Refrigerated

7days

Stability Frozen

>7 days

CPT Code

86704

Days Test Set Up

Monday through Friday

Clinical Information

Hepatitis B core antigen, found in liver cells, does not circulate in the bloodstream. However, IgM and IgG antibodies to the HBcAg can be detected serologically in HBV infected individuals. Anti-HBc IgM is detectable first and remains detectable for approximately six months. Shortly after the IgM response, anti-HBc IgG appears and can remain detectable indefinitely.
The presence of anti-HBc IgM and anti-HBc IgG is characteristic of acute infection, while the presence of anti-HBc IgG without IgM is characteristic of chronic or recovered stages of HBV infection. Anti-HBc Total detects both antibodies. Most often levels of anti-HBc will coincide with detecteable levels of other HBV markers. Rarely, anti-HBc may be the only detectable marker. This may occur during the brief period when hepatitis B surface antigen has been cleared from the bloodstream and before antibodies to hepatitis B surface antigen become detectable. For this reason, the ue of the anti-HBc Total assays to detect acute infection is not recommended. It should be used in conjunction with other marker assays to assess current or past exposure to HBV

Test Use

For the qualitative determination of total antibodies to the core antigen of the hepatitis B virus. This assay can be used as an aid in the diagnosis of individuals with acute or chronic hepatitis B virus infection and in the determination of the clinical status of HBV infected individuals in conjunction with other HBV serological markers for the lab diagnosis of HBV disease associated with HBV infection.

Interpretation

Negative is considered nonreactive for total antibodies to hepatitis B core antigen.
Positive is considered reactive for total antibodies to hepatitis B core antigen.