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Test Code IGGS IgG Subclasses, Serum


Advisory Information


If testing for immunoglobulin (Ig) G4-related diseases, the more appropriate test to order is IGGS4 / Immunoglobulin Subclass IgG4, Serum.



Specimen Required


Patient Preparation: Fasting preferred but not required

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL


Forms

If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.

Secondary ID

800191

Useful For

Second-order testing for evaluation of patients with clinical signs and symptoms of humoral immunodeficiency or combined immunodeficiency (cellular and humoral)

Method Name

Nephelometry

Reporting Name

IgG Subclasses, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Reference Values

TOTAL IgG

0-<5 months: 100-334 mg/dL

5-<9 months: 164-588 mg/dL

9-<15 months: 246-904 mg/dL

15-<24 months: 313-1,170 mg/dL

2-<4 years: 295-1,156 mg/dL

4-<7 years: 386-1,470 mg/dL

7-<10 years: 462-1,682 mg/dL

10-<13 years: 503-1,719 mg/dL

13-<16 years: 509-1,580 mg/dL

16-<18 years: 487-1,327 mg/dL

≥18 years: 767-1,590 mg/dL

 

IgG1

0-<5 months: 56-215 mg/dL  

5-<9 months: 102-369 mg/dL

9-<15 months: 160-562 mg/dL

15-<24 months: 209-724 mg/dL

2-<4 years: 158-721 mg/dL

4-<7 years: 209-902 mg/dL

7-<10 years: 253-1,019 mg/dL

10-<13 years: 280-1,030 mg/dL

13-<16 years: 289-934 mg/dL

16-<18 years: 283-772 mg/dL

≥18 years: 341-894 mg/dL

 

IgG2

0-<5 months: ≤82 mg/dL

5-<9 months: ≤89 mg/dL

9-<15 months: 24-98 mg/dL

15-<24 months: 35-105 mg/dL

2-<4 years: 39-176 mg/dL

4-<7 years: 44-316 mg/dL

7-<10 years: 54-435 mg/dL

10-<13 years: 66-502 mg/dL

13-<16 years: 82-516 mg/dL

16-<18 years: 98-486 mg/dL

≥18 years: 171-632 mg/dL

 

IgG3

0-<5 months: 7.6-82.3 mg/dL

5-<9 months: 11.9-74.0 mg/dL

9-<15 months: 17.3-63.7 mg/dL

15-<24 months: 21.9-55.0 mg/dL

2-<4 years: 17.0-84.7 mg/dL

4-<7 years: 10.8-94.9 mg/dL

7-<10 years: 8.5-102.6 mg/dL

10-<13 years: 11.5-105.3 mg/dL

13-<16 years: 20.0-103.2 mg/dL

16-<18 years: 31.3-97.6 mg/dL

≥18 years: 18.4-106.0 mg/dL

 

IgG4

0-<5 months: ≤19.8 mg/dL

5-<9 months: ≤20.8 mg/dL

9-<15 months: ≤22.0 mg/dL

15-<24 months: ≤23.0 mg/dL

2-<4 years: 0.4-49.1 mg/dL

4-<7 years: 0.8-81.9 mg/dL

7-<10 years: 1.0-108.7 mg/dL

10-<13 years: 1.0-121.9 mg/dL

13-<16 years: 0.7-121.7 mg/dL

16-<18 years: 0.3-111.0 mg/dL

≥18 years: 2.4-121.0 mg/dL

Day(s) and Time(s) Performed

Monday through Friday, Sunday; 12 a.m.-6 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Florida

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82784

82787 x 4

LOINC Code Information

Test ID Test Order Name Order LOINC Value
IGGS IgG Subclasses, S 47289-4

 

Result ID Test Result Name Result LOINC Value
T_IGG Total IgG 2465-3
IGG1 IgG 1 2466-1
IGG2 IgG 2 2467-9
IGG3 IgG 3 2468-7
IGG4 IgG 4 2469-5

Testing Algorithm

Testing includes total immunoglobulin G (IgG) as well as the 4 subclasses of IgG.

 

See Celiac Disease Diagnostic Testing Algorithm in Special Instructions